CLSI Performance Standards for AST
 
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CMPT lists the latest versions of CLSI documents as a service to participants. It is important for laboratories to stay updated on the latest recommendations on susceptibility testing and interpretation.

The Clinical and Laboratory Standards Institute develops standards and guidelines for implementation as best practices in clinical laboratory testing to improve patient care worldwide. CLSI ’s consensus-driven development process balances the viewpoints of industry, government, and the healthcare professions.

The mission of the Subcommittee on Antimicrobial Susceptibility Testing is to:
 • Develop standard reference methods for antimicrobial susceptibility tests;
 • Provide quality control parameters for standard test methods;
 • Establish interpretive criteria for results of standard antimicrobial susceptibility tests;
 • Provide suggestions for testing and reporting strategies that are clinically relevant and  cost-effective;

The ultimate purpose of the subcommittee’s mission is to provide useful information to enable laboratories to assist the clinician in the selection of appropriate antimicrobial therapy for patient care. 

Latest versions of main AST CLSI documents and Updates (for complete list please visit CLSI website)

M2-A10 Performance Standards for Antimicrobial Disk Susceptibility Tests (2008)
M7-A8 Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria That Grow Aerobically (2008)
M11-A7 Methods for Antimicrobial Susceptibility Testing of Anaerobic Bacteria (2007)
M23-A3 Development of In Vitro Susceptibility Testing Criteria and Quality Control Parameters (2008)
M27-A3 Reference Method for Broth Dilution Antifungal Susceptibility Testing of Yeasts (2008)
M38-A2 Reference Method for Broth Dilution Antifungal Susceptibility Testing of Filamentous Fungi (2008)
M39-A3 Analysis and Presentation of Cumulative Antimicrobial Susceptibility Test Data (2009)
M44-A2 Method for Antifungal Disk Diffusion Susceptibility Testing of Yeasts (2009)
M45-A Methods for Antimicrobial Dilution and Disk Susceptibility Testing of Infrequently Isolated or Fastidious Bacteria (2006)
M100-S20 Performance Standards for Antimicrobial Susceptibility Testing (2010) NEW!!
Updates include
Revised cephalosporin and aztreonam breakpoints for Enterobacteriaceae, that alleviate the need for routine extended-spectrum‚ β-lactamase (ESBL)
 
New quality control ranges for antimicrobial agents.

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